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We suggest that chloroquine exerts its antimalarial activity by causing a build-up of toxic membrane-associated haem molecules that eventually destroy the integrity of the malaria parasite.
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Some public aquariums have been using and recommending the use of chloroquine for quite some time now with very positive results, as indicated by the discussions on the Aquatic Info Serve, which is an information exchange service for public and professional aquarists, hosted by the New England Aquarium and moderated by Brian Nelson.
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Once you get that first CCC established in a population, the odds of developing a second one are not CCC squared.
The drug or drug combinations recommended for treatment are listed in bold on the first line of each box in the adult and pediatric "drug and dose" columns.
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Each year, 30 million pregnancies are at risk of malaria infection in sub-Saharan Africa, representing a major public health problem.
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After a single dose of 14C-etodolac, hydroxylated metabolites accounted for less than 10% of total drug in serum.
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Chloroquine (CQ) accumulates in the food vacuole of the parasite.
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Given that trastuzumab's mechanism of action involves HER2 internalization and recycling via chloroquine-targeted lysosomal pathway-dependent degradation, we then evaluated whether adding chloroquine to trastuzumab might uncover a previously unrecognized synthetic lethal interaction.
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She explained "the Global Technical Strategy has three main pillars: Universal access - to ensure that all people in need will have access to malaria control intervention-; acceleration, for elimination in all affected countries, which is the second pillar.
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These data clearly show that addition of chloroquine can effectively reduce the establishment of infection and spread of SARS-CoV if the drug is added immediately following virus adsorption.
In animals, activation of the protein ataxia telangiectasia mutated (ATM) using the antimalarial drug chloroquine improves features of metabolic syndrome and decreases atherosclerosis, a build-up of fatty plaque within arteries.
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Patients should be strongly warned to keep this drug out of the reach of children because they are especially sensitive to the 4-aminoquinoline compounds.
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Quinine and chloroquine have been used to treat completely different diseases (such as malaria), but are also very bitter.
If a drug or drug combination used in IPTp is not simultaneously used for clinical malaria case management, then IPTp may actually lower the selection pressure on the first-line drug by decreasing symptomatic cases that require treatment.
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ABSTRACT: A self-limiting psychosis characterized by visual and auditory hallucinations and isomnia occurred in a 17-year old male after mefloquine administration for presumed chloroquine resistant falciparum malaria.
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The rapid spread of CQ and SP resistance may be due to some degree to high gametocyte carriage after treatment and treatment failure ().
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However, in both settings, there were some inconsistencies, with relatively high rates of gametocyte carriage during times when asexual parasite carriage was low or declined and stable rates of gametocyte production during the dry season ().
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